| 对氧磷脂酶1与2型糖尿病血管并发症的关系研究 |
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| 引用本文： | 郭建政. 对氧磷脂酶1与2型糖尿病血管并发症的关系研究[J]. 现代保健, 2012, 0(6): 3-5 |
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| 作者姓名： | 郭建政 |
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| 作者单位： | 河北省邯郸市人民医院,056000 |
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| 摘 要： | 目的探讨血清对氧磷脂酶1活性与2型糖尿病血管并发症的关系。方法以对氧磷为底物测定2型糖尿病各组患者及健康老年人血清对氧磷脂酶1活性。结果 2型糖尿病组与健康对照组血清对氧磷脂酶1活性差异有统计学意义（P〈0.01）;2型糖尿病合并血管病变组与2型糖尿病组血清对氧磷脂酶1活性差异有统计学意义（P〈0.01）。结论对氧磷脂酶1活性在2型糖尿病及并发血管病变患者中均显著降低,提示对氧磷脂酶1活性的降低参与了糖尿病血管并发症的发生。
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| 关 键 词： | 对氧磷脂酶1 糖尿病 2型糖尿病 糖尿病血管病变 |
A study on the relationship between paraoxonase 1 and type 2 diabetes mellitus with vascular complications |
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| GUO Jian-zheng. A study on the relationship between paraoxonase 1 and type 2 diabetes mellitus with vascular complications[J]. , 2012, 0(6): 3-5 |
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| Authors: | GUO Jian-zheng |
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| Affiliation: | GUO Jian-zheng. Handan People＇s Hospital, Handan 056000, China |
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| Abstract: | Objective To study the relationship between serum paraoxonase 1（PON1） activity and type 2 diabetes mellitus with vascular complications in the elderly.Methods Serum PON1 activity was measured by using paraoxonase as the substrate among the elderly with type 2 diasetes and the normal healthy people.Results PON1 activity was much lower in the elderly groups with type 2 diabetes mellitus than that of the controls, and PON1 activity was much lower in type 2 diabetic patients combined with macroangiopathy and microangiopathy than that of the simple type 2 diabetic patients （P〈0.01）. Serum PON1 activity was much lower in the elderly patients with type 2 diabetes mellitus and diabetic vascular complications.Conclusion The lower serum PON1 activity may play a role in elderly patients with type 2 diabetes mellitus and diabetic vascular complications. |
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| Keywords: | Paraoxonase 1 Diabetes mellitus Type 2 diabetes Diabetic angiopathies |
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