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Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients |
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| Authors: | Walderez O Dutra Rodrigo Correa-Oliveira David Dunne Luiza Fosenca Cecchini Lúcia Fraga Morven Roberts Alda Maria Soares-Silveira Michelle Webster Hans Yssel Kenneth J Gollob |
| Affiliation: | 1. Departamento de Morfologia, ICB-UFMG, Belo Horizonte, MG, Brazil 2. Centro de Pesquisas "René Rachou", FIOCRUZ, Belo Horizonte, MG, Brazil 3. Department of Pathology, Division of Parasitology, Cambridge University, Cambridge, UK 4. Departamento de Bioquímica-Imunologia, ICB-UFMG, Belo Horizonte, MG, Brazil 5. Escola de Odontologia, UNIVALE, Governador Valadares, MG, Brazil 7. DNAX Research Inst., Palo Alto, CA, USA 8. INSERM, Montpellier, France 6. Division of Parasitic Diseases, NICD, Centers for Disease Control, Atlanta, GA, USA |
| Abstract: | BackgroundHuman resistance to re-infection with S. mansoni is correlated with high levels of anti-soluble adult worm antigens (SWAP) IgE. Although it has been shown that IL-4 and IL-5 are crucial in establishing IgE responses in vitro, the active in vivo production of these cytokines by T cells, and the degree of polarization of Th2 vs. Th0 in human schistosomiasis is not known. To address this question, we determined the frequency of IL-4 and IFN-γ or IL-5 and IL-2 producing lymphocytes from schistosomiasis patients with high or low levels of IgE anti-SWAP. |
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