| 291例HIV感染者合并HCV及HSV-2感染状况及相应免疫特征分析 |
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| 引用本文： | 苏莹珍,马艳玲,贾曼红,陆林,杨莉,陈玲,陈会超,杨朝军,施玉华,俞守义.291例HIV感染者合并HCV及HSV-2感染状况及相应免疫特征分析[J].广东寄生虫学会年报,2011(1):23-25,53. |
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| 作者姓名： | 苏莹珍 马艳玲 贾曼红 陆林 杨莉 陈玲 陈会超 杨朝军 施玉华 俞守义 |
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| 作者单位： | [1]云南省疾病预防控制中心性病艾滋病防制科,云南昆明650022 [2]南方医科大学公共卫生与热带医学学院流行病学系,广东广州510515 |
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| 基金项目： | 艾滋病和病毒性肝炎等重大传染病防治项目（2009ZX10004-902） |
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| 摘 要： | 目的了解HIV感染者中HCV及HSV-2合并感染的情况及CD4＋T细胞免疫特征。方法用ELISA方法检测291例HIV感染者的抗HCV及HSV-2抗体,对HIV感染者进行CD4＋T淋巴细胞绝对计数和其占T淋巴细胞的百分比分析。结果 HIV合并HCV感染43例,合并HSV-2感染99例,合并HCV和HSV-2感染31例。CD4＋T淋巴细胞百分比以合并感染HCV组最高（78.4%）,合并感染HSV-2组和无合并感染次之,合并感染HCV和HSV-2组最低,组间差异无统计学意义。CD4＋T淋巴细胞绝对数以合并感染HCV和HSV-2组最低,合并感染HCV组、合并感染HSV-2组居中,无合并感染组最高,组间差异无统计学意义。结论 HIV感染者合并HCV、HSV-2感染率较高,HIV合并HCV和HSV-2感染时,CD4＋T细胞绝对数和CD4＋T淋巴细胞百分比下降,加重损害机体的免疫系统。
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| 关 键 词： | HIV 合并感染 HCV HSV-2 |
The analysis of immune characters and features of co-infection of HCV and HSV-2 among 291 HIV patients |
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| SU Ying-zhen,MA Yan-ling,JIA Man-hong,LU Lin,YANG Li,CHEN Ling,CHEN Hui-chao,YANG Chao-jun,SHI Yu-hua,YU Shou-yi.The analysis of immune characters and features of co-infection of HCV and HSV-2 among 291 HIV patients[J].Journal of Tropical Medicine,2011(1):23-25,53. |
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| Authors: | SU Ying-zhen MA Yan-ling JIA Man-hong LU Lin YANG Li CHEN Ling CHEN Hui-chao YANG Chao-jun SHI Yu-hua YU Shou-yi |
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| Institution: | 1.Center for AIDS/STDs Prevention and Control,Yunnan Center for Disease Control and Prevention,Yunnan,Kunming 650022;2.Department of Epidemiology,School of Public Health and Tropical Medicine,Southern Medical University,Guangdong,Guangzhou 510515,China) |
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| Abstract: | Objective To investigate the CD4＋T lymphocyte characters of HIV-positive patients who were co-infected with HCV and HSV-2.Method The antibody of HCV and HSV-2 were detected by ELISA,and CD4＋T lymphocyte and percentage were analyzed by FCM（Flow cytometry）.Results 43 patients were co-infected with HCV,and 99 patients were co-infected with HSV-2,and 31 patients were co-infected with HCV and HSV-2.The percentage of CD4＋T cell in T lymphocyte among HIV patients who were co-infected with HCV and HSV-2 is lower than the other groups.The absolute number of CD4＋T cell in group of HIV patients is higher than the other groups,but the difference among groups is not significant.Conclusion The prevalence of co-infected with HCV and HSV-2 is high among HIV-positive patients.The absolute number of CD4＋T lymphocyte and the percentage of CD4＋T cell in T lymphocyte among HIV-positive patients who are co-infected with HCV and HSV-2 is lower.This may be due to the damage of CD4＋ T lymphocyte in immune system. |
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| Keywords: | HIV co-infection HCV HSV-2 |
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