2型糖尿病肾病Ⅲ期的中医用药规律分析

目的分析和了解中医药治疗2型糖尿病肾病Ⅲ期的用药规律。方法选用维普咨询中文科技期刊数据库（1989-2009）、中国期刊全文数据库（CNKI）（1979-2009）、万方数据库（1982-2009）、中国生物医学文献数据库（CBM）（1990-2009）、中文生物医学期刊数据库（CMCC/CMCI）（1994-2009）为资料源,对中医药治疗2型糖尿病肾病Ⅲ期的随机对照文献的用药规律进行统计分析。结果检索到有效文献223篇,共涉及138种中药,用药频次居于前10位的是黄芪、丹参、山茱萸、山药、生地黄、川芎、茯苓、当归、益母草、大黄。药类频次统计显示,益气药居于首位,活血、养阴、收涩、清热、利水渗湿、破血逐瘀药也占了相当大的比重。结论 2型糖尿病肾病III期的中医用药多以益气养阴活血药为主,同时辅以清热、淡渗利湿、收涩固摄、化瘀泄浊、疏风解表等药,并结合临床常用经验方或药对,取得了良好的疗效。

Application of Chinese medicine in type-2 early-stage diabetic nephropathy

Objective To study the medication pattern of traditional Chinese medicine in the treatment of type-2 early-stage diabetic nephropathy.Methods A literature survey on the medication pattern of randomized and controlled trials between 1984 and 2009 was conducted.Information from CNKI,wanfang data,CBM and CMCC concerning the use of traditional Chinese medicine and integrative medicine in the treatment of type-2 early-stage diabetic nephropathy was analyzed by Statistical Methods.Results 233 valid literatures,involving 138 kinds of herbs,were retrieved.The top 10 frequently used herbs were Astragalus,Salvia,Dogwood,Yam,Rehmanniae Root,Szechwan Lovage Rhizome,Tuckahoe,Angelica,Motherwort,and Rhubarb.Nourishing qi drugs were the most frequently used,followed by the drugs for activating blood circulation,nourishing yin,astringent,clearing heat,light penetration dampness,and dissipate blood stasis drugs.Conclusion In the treatment of patients with type-2 early-stage diabetic nephropathy,management of nourishing qi and yin as well as activating blood circulation are the basis of the treatment.A good therapeutic effect can be achieved when the treatment was complement with clearing heat,light penetration dampness,astringent astringent,dissipate blood stasis,expelling wind,and other drugs.