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Longitudinal study of a mouse model of chronic pulmonary inflammation using breath hold gated micro-CT

Authors:	Xabier Artaechevarria David Blanco Daniel Pérez-Martín Gabriel de Biurrun Luis M Montuenga Juan P de Torres Javier J Zulueta Gorka Bastarrika Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano

Institution:	(1) Cancer Imaging Laboratory, Oncology Division, Center for Applied Medical Research, University of Navarra, 55 Pio XII, 31008 Pamplona, Spain;(2) Biomarkers Laboratory, Oncology Division, Center for Applied Medical Research, University of Navarra, 55 Pio XII, 31008 Pamplona, Spain;(3) Pneumology Department, Clinica Universidad de Navarra, 36 Pio XII, 31008 Pamplona, Spain;(4) Radiology Department, Clinica Universidad de Navarra, 36 Pio XII, 31008 Pamplona, Spain

Abstract:	Objectives To evaluate the feasibility of using automatic quantitative analysis of breath hold gated micro-CT images to detect and monitor disease in a mouse model of chronic pulmonary inflammation, and to compare image-based measurements with pulmonary function tests and histomorphometry.

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