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Hydrogen inhalation ameliorates ventilator-induced lung injury
Authors:Chien-Sheng Huang  Tomohiro Kawamura  Sungsoo Lee  Naobumi Tochigi  Norihisa Shigemura  Bettina M Buchholz  John D Kloke  Timothy R Billiar  Yoshiya Toyoda  Atsunori Nakao
Affiliation:(1) Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA;(2) Division of Thoracic Surgery, Department of Surgery, Taipei-Veterans General Hospital and National Yang-Ming University School of Medicine, No.201 Sec.2, Shih-Pai Rd, Taipei, 112, Taiwan;(3) Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, 15213, PA, USA;(4) Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, San 5, Woncheon-dong, Youngtong-gu, Suwon, 443-749, South Korea;(5) Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, 15213, PA, USA;(6) Department of Medicine, Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, 15213, PA, USA;(7) Center for Research on Health Care Data Center, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, 15213, PA, USA;(8) Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, 15213, PA, USA
Abstract:

Introduction  

Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, and subsequently cause ventilator-induced lung injury (VILI), a major cause of mortality and morbidity of patients in the intensive care unit. Inhaled hydrogen can act as an antioxidant and may be useful as a novel therapeutic gas. We hypothesized that, owing to its antioxidant and anti-inflammatory properties, inhaled hydrogen therapy could ameliorate VILI.
Keywords:
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