Increased sinusoidal flow is not the primary stimulus to liver regeneration |
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| Authors: | Kim E Mortensen Lene N Conley Ingvild Nygaard Peter Sorenesen Elin Mortensen Christian Bendixen Arthur Revhaug |
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| Institution: | (1) Surgical Research Laboratory, Institute of Clinical Medicine, University of Tromsoe, Tromsoe, Norway;(2) Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, University of Aarhus, Aarhus, Denmark;(3) Department of Pathology, University Hospital of Northern-Norway, Tromsoe, Norway;(4) Department of Gastrointestinal Surgery, University Hospital of North-Norway, Tromsoe, Norway |
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| Abstract: | Background Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus
in triggering liver regeneration. We hypothesized that it is the increased sinusoidal flow per se and hence the shear-stress
stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test
this hypothesis we wanted to increase the sinusoidal flow without performing a concomitant liver resection. Accordingly, we
constructed an aorto-portal shunt to the left portal vein branch creating a standardized four-fold increase in flow to segments
II, III and IV. The impact of this manipulation was studied in both an acute model (6 animals, 9 hours) using a global porcine
cDNA microarray chip and in a chronic model observing weight and histological changes (7 animals, 3 weeks). |
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