Dextran-magnetite: a contrast agent for sodium-23 MRI |
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| Authors: | R M Summers P M Joseph P F Renshaw H L Kundel |
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| Affiliation: | Pendergrass Diagnostic Radiology Research Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104. |
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| Abstract: | Dextran-magnetite, a superparamagnetic compound, is a powerful relaxation reagent for sodium. Administered intravenously, it is confined mainly to the vasculature and eliminates the signal from plasma sodium, a significant component of the tissue sodium signal. Applications of dextran-magnetite for in vivo sodium imaging of a normal rat and rats with a tumor and experimentally induced peripheral edema are shown. Our results indicate that dextran-magnetite may be useful for improving tumor detection and for imaging of edema. To our knowledge, this is the first report of a contrast agent suitable for sodium magnetic resonance imaging. |
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