女性骨关节炎患者关节液visfatin水平与CTX-Ⅱ的相关分析

目的研究女性骨关节炎患者关节液visfatin水平与CTX-Ⅱ的相关分析。方法利用ELISA方法测定30例OA患者及12例对照组血浆和关节液visfatin及CTX-Ⅱ水平。结果 OA患者关节液visfatin浓度明显高于对照组（8.95±2.51ng/ml vs 4.48±2.49ng/ml,P〈0.001）,两组血浆visfatin浓度无统计学意义（5.37±1.45ng/ml vs 4.93±1.4ng/ml,P=0.466）。关节液visfatin水平与Ⅱ型胶原降解产物CTX-Ⅱ呈正相关（r=0.497,P〈0.01）,与hsCRP无相关（r=-0.246,P=0.19）。K-LⅣ级OA患者关节液visfatin浓度明显高于K-LⅢ级visfatin浓度（10.57±2.49ng/ml vs 7.54±1.5ng/ml,P〈0.01）。关节液visfatin水平明显与OA严重程度正相关（r=0.421,P=0.021）。结论 Visfatin可能通过关节腔局部作用参与OA关节软骨降解通路。

Correlation between visfatin and CTX-H levels in synovial fluid of female patients with osteoarthritis

Objective To investigate the correlation between synovial fluid visfatin and CTX-Ⅱlevels of female patients with osteoarthritis.Methods Plasma and synovial fluid visfatin and CTX-Ⅱlevels of 30 OA patients and twelve control subjects were measured by ELISA.Results Compared to controls,OA patients had higher synovial fluid visfatin concentration（8.95±2.5 ng/ml vs 4.48±2.49 ng/ml,P0.001）.Plasma visfatin levels were higher in OA patients than those in control subjects,but not statistical significance（5.37±1.45 ng/ml vs 4.93±1.4 ng/ml,P = 0.466 ）. Synovial fluid visfatin positively correlated with CTX-Ⅱ（r=0.497,P0.01）,but not correlated with hs CRP（r=- 0.246,P = 0.19）.The synovial fluid visfatin levels from KL gradeⅣwere higher than those from KL gradeⅢ（10.57±2.49 ng/ml vs 7.54±1.5 ng/ml,P0.01 ）.Synovial fluid visfatin is positively correlated with OA severity（r = 0.421,p = 0.021）.Conclusion Visfatin may have local effects during the articular cartilage degradation pathway in OA.