证候蛋白质组学与中医证候学相关性探讨

以蛋白质组学为代表的后基因组时代的到来，必然使分子生物学经历从局部观走向整体观、从线形思维走向复杂思维的转变。基于蛋白质组学的发展趋势，总结了近年来中医证候学研究方法，提倡用二维电泳及生物信息学方法鉴定不同的蛋白质。将蛋白质组学引入中医证候分类及证候演变规律的研究，对从分子流行病学水平来探讨中医学与蛋白质组学乃至现代分子生物学研究相结合都是必须的。而蛋白质组学与传统中医药在研究生命科学的思维方法上逐步趋于一致，相互渗透，说明在探讨复杂性生命现象时中西医两种医学相结合的必然性和重要性。

Exploration on Correlation of Syndrome Proteomics and Syndromatology of TCM

The advent of the Post-Human Genome Project Era, represented by the raising of proteomics, would inevitably lead to the change of molecular biology from topical view to holistic with its thought turning from linear to complex mode. Based on the proteomics development in recent years, the authors summarized the methodology of TCM syndromatologic research, advocated in using two-dimensional gel electrophoresis (2-DE) and bioinformatics to identify different proteins. Proteomics should be led into the research of TCM syndrome categorization and the rule of evolution, which is necessary for researching the integration of the TCM study with proteomics and even with modern molecular biology based on molecular epidemiology level. Owing to the gradually developed coherence and mutual penetration of proteomics and TCM on the thinking method in studying life science, it has denoted the necessity and importance of integration of TCM and Western medicine in investigating the complex vital life phenomena.