| 表皮生长因子受体在肝细胞癌及胆管细胞癌中的表达 |
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| 引用本文： | 顾广玉,朱明华,王文亮,詹洲.表皮生长因子受体在肝细胞癌及胆管细胞癌中的表达[J].临床与实验病理学杂志,1999,15(5):385-386. |
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| 作者姓名： | 顾广玉 朱明华 王文亮 詹洲 |
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| 作者单位： | 1. 第二军医大学长海医院病理科,上海,200433
2. 第四军医大学病理学教研室,西安,710038 |
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| 摘 要： | 目的：比较表皮生长因子受体（ＥＧＦＲ） 在肝细胞癌及胆管细胞癌中表达的差异。方法：采用免疫组化及原位杂交方法检测９２ 例肝细胞癌及５０ 例胆管细胞癌组织中ＥＧＦＲ蛋白及ｍ ＲＮＡ的表达。结果：９２ 例肝细胞癌标本中，４２ 例ＥＧＦＲ 蛋白或ｍＲＮＡ阳性，占４５－７％ 。５０ 例胆管细胞癌中，３６ 例ＥＧＦＲ蛋白或ｍＲＮＡ 阳性，占７２－０ ％ 。结论：与肝细胞癌相比，胆管细胞癌的发生、发展与ＥＧＦＲ 表达增高的关系更加密切。
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| 关 键 词： | 癌 肝细胞 胆管癌 受体 表皮生长因子 原位杂交 |
| 修稿时间： | 1998-12-11 |
Expression of epidermal growth factor receptor(EGFR) in hepatocellular carcinoma and cholangiocarcinoma |
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| Gu Guangyu,Zhu Minghua,Wang Wenliang et al.Expression of epidermal growth factor receptor(EGFR) in hepatocellular carcinoma and cholangiocarcinoma[J].Chinese Journal of Clinical and Experimental Pathology,1999,15(5):385-386. |
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| Authors: | Gu Guangyu Zhu Minghua Wang Wenliang |
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| Abstract: | Purpose To explore the difference in the expression of epidermal growth factor receptor (EGFR) between hepatocellular carcinoma and cholangiocarcinoma. Methods Immunohistochemical technique and in situ hybridization technique were used to detect EGFR protein and EGFR mRNA. Results Forty two cases(45 7%) were positive for EGFR protein or EGFR mRNA in 92 cases of hepatocellular carcinoma, 36 cases(72 0%) were positive for EGFR protein or EGFR mRNA in 50 cases of cholangiocarcinoma. Conclusion The high expression of EGFR may play more important role in pathogenesis of cholangiocarcinoma than in pathogenesis of hepatocellular carcinoma. |
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| Keywords: | carcinoma hepatocellular cholangiocarcinoma receptors epidermal growth factor in situ hybridization |
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