膀胱移行细胞癌肿瘤血管生成的研究

为探讨肿瘤微血管与膀胱移行细胞癌浸润和转移的关系，应用免疫组织化学技术在６４例膀胱移行细胞癌组织中对第Ⅷ因子相关抗原进行表达，并计数肿瘤的微血管（ＭＶ）。结果发现，术后复发者ＭＶ数明显高于未复发者（Ｐ＜００１），浸润性癌的ＭＶ数明显高于浅表性癌（Ｐ＜００１），组织学Ⅲ级高于Ⅰ、Ⅱ级（Ｐ＜００５），伴淋巴结转移的ＭＶ数显著高于未转移者（Ｐ＜００５）。结果提示以ＭＶ为标记的肿瘤血管与膀胱移行细胞癌的分期、分级及预后密切相关，肿瘤的增长和转移有赖于肿瘤血管的生成。

Tumor angiogenesis in transitional cell carcinoma of bladder

To evaluate angiogenesis as a prognostic marker of transitional cell carcimoma of bladder ,64 tissue specimens of transitional cell carcinoma of bladder were examined and microvessels were highlighted for factor VIII related antigen by means of immunostaining the endothelial cells. The result revealed that the microvessel counts (MVC)in tumor tissues of patients with recurrence was significantly higher than in those without recurrence ( P <0.01).There was also a significant difference of MVC between superficial and infiltrative lesions ( P <0.01),between grade III and grade I,II tumors ( P <0.01),between those with lymph node metastasis and those without metastasis ( P <0.05).It was suggested that angiogenesis assessed by micro vessel counts correlated positively with recurrence after surgical resection as both tumor growth and tumor metastasis require angiogenesis.