The Use of Flexible Hysterofiberscope (FUJINON) in Transcervical Chorionic Villi Sampling, and Its Evaluation |
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| Authors: | Kazuhiko HAYASHI Keisuke NOSAKA Michie IWATA Koh ISHIJIMA Hiroshi HAMADA Manabu NAGAE Norie KANAMORI Yoshikazu KUROKI |
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| Affiliation: | Department of Obstetrics and Gynecology, St. Marianna University, School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 213, Japan;Department of Clinical Laboratory, St. Marianna University, School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 213, Japan;Division of Medical Genetics, Kanagawa Children's Medical Center, Mutsukawa 2-138-4, Minami-ku, Yokohama 232, Japan |
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| Abstract: | Abstract Under real-time ultrasonographic guidance, chorionic villi sampling (CVS) was performed either by direct punch biopsy with FUJINON therapeutic flexible hysterofiberscope (HYS-FT), or by catheter aspiration biopsy after observation with FUJINON hysterofiberscope (HYS-F). The former method was performed in 2 pregnant women, the latter in 11. The chorion frondosum was observed three dimensionally in all cases. Except for one unsuccessful sampling in our first cases in which CVSs were performed, all attempts were successful, and diagnoses duly completed (11 cases of chromosome analyses and one case of DNA analysis). No serious complications appeared in any case immediately after sampling or on the 1st and 7th days. Ultrasonography showed no adverse effects on fetal heart rate, no hematoma at the site of CVS and no injury to the gestational sac. Uterine bleeding was rarely witnessed. Except for one spontaneous abortion and one intra-uterine fetal death (IUFD) due to placenta previa, all other newborns were healthy. With some improvements, this CVS is believed to be an effective method. |
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| Keywords: | hysterofiberscope chorionic villi sampling chromosome analysis DNA analysis |
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