Randomized comparison of new dual-antiplatelet therapy (aspirin,prasugrel) and triple-antiplatelet therapy (aspirin,clopidogrel, cilostazol) using P2Y12 point-of-care assay in patients with STEMI undergoing primary PCI |
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Authors: | Tae-Hyun Yang Han-Young JinKyu-Nam Choi Ungjeong DoHyung Jun Kim Sang-Ryul ChungJeong-Sook Seo Jae-Sik JangDae-Kyeong Kim Dong-Soo Kim |
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Affiliation: | Division of Cardiology, Department of Internal Medicine, Inje University College of Medicine, Cardiovascular Research Institute, Busan Paik Hospital, Busan, South Korea |
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Abstract: | BackgroundBoth new dual antiplatelet therapy (DAT; aspirin and prasugrel) and triple antiplatelet therapy (TAT; aspirin, clopidogrel and cilostazol) are more potent than classic DAT (aspirin and clopidogrel). We compared the antiplatelet efficacy between new DAT and TAT in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary coronary percutaneous coronary intervention (PCI).MethodsForty patients who were eligible for primary PCI were prospectively randomized to DAT group (n = 20) or TAT group (n = 20) immediately after hospital arrival. The primary end point was P2Y12 reaction unit (PRU) determined with the VerifyNow P2Y12 point-of-care assay at the time of discharge.ResultsPRU value at discharge was significantly lower in patients receiving DAT compared with that of TAT (84.5 ± 44.7 vs. 128.4 ± 74.9, p = 0.032). Percent platelet inhibition was significantly higher for DAT compared with TAT at discharge (72.1 ± 12.2 vs. 57.5 ± 23.5, p = 0.020). Inter-patient variability of PRU values at discharge was significantly smaller in patient taking DAT compared with TAT (p = 0.026).ConclusionA new DAT is more potent antiplatelet therapy than TAT in patients with STEMI undergoing primary PCI. |
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Keywords: | Prasugrel Clopidogrel Cilostazol Point-of-care systems |
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