Inhibition of hepatitis C virus infection by polyoxometalates |
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Authors: | Yue Qi Yu Xiang Juan Wang Yanfei Qi Juan Li Junqi Niu Jin Zhong |
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Affiliation: | 1. Department of Hepatology, First Hospital, Jilin University, Changchun, Jilin 130021, China;2. Unit of Viral Hepatitis, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;3. School of Public Health, Jilin University, Changchun, Jilin 130021, China |
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Abstract: | Hepatitis C virus (HCV) infects about 2% of the world population. The standard treatment of chronic HCV infection is still discontented because of the low sustained virological response rate. The development of new HCV antivirals is a healthcare imperative. We explored the potentials of polyoxometalates to inhibit HCV infection using newly developed HCVcc cell culture system. We found one polyoxometalate compound (named POM-12) can inhibit HCV infection at the nanomolar range while displayed little cytotoxicity. We showed that POM-12 inhibited pseudotyped HCV infection but had no effect on HCV RNA replication. Furthermore, we showed that POM-12 was virucidal and can disrupt HCV particles. Finally we demonstrated that POM-12 had no effect on the vesicular stomatitis virus infection while had weak inhibitory activity against the influenza virus infection. In conclusion, we identified a potent anti-HCV compound which may provide an attractive drug candidate to cure HCV infection. |
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Keywords: | Polyoxometalate Antiviral Hepatitis C virus Virucidal |
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