| 人宫颈癌基因在胃癌中的表达及其意义 |
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| 引用本文： | 朱敏,邓长生,王军文. 人宫颈癌基因在胃癌中的表达及其意义[J]. 临床消化病杂志, 2008, 20(6). DOI: 10.3870/j.issn.1005-541X.2008.06.014 |
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| 作者姓名： | 朱敏 邓长生 王军文 |
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| 作者单位： | 武汉大学中南医院消化内科,武汉,430070;武汉大学中南医院消化内科,武汉,430070;武汉大学中南医院消化内科,武汉,430070 |
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| 摘 要： | 目的 探讨人宫颈癌基因(human cervical cancer oncogene,HCCR)在人胃癌组织和胃癌细胞株中的表达及其与临床病理特征的关系,初步评价HCCR在胃癌发生中的作用及其意义,为寻找胃癌新的诊断标志物另辟新径.方法 采用Western blot方法检测SGC-7901、BGC-823胃癌细胞系中HCCR蛋白表达;采用免疫组化法检测30例胃癌患者的癌组织和10例癌旁正常组织中HCCR蛋白表达.结果 HCCR蛋白在两种不同分化程度的胃癌细胞株中均有阳性表达;胃癌组织中HCCR阳性表达率为73.3%(22/30),其表达位于细胞的胞膜和胞质,10例癌旁正常组织均为阴性表达,两者差异具有统计学意义(P＜0.01).HCCR的表达与胃癌患者的年龄、性别、浸润深度、组织分型、肿瘤分化程度及有无淋巴结转移均无显著相关性(P＞0.05).结论 HCCR与胃癌的发生密切相关,可能是反映早期胃癌发生的重要生物学指标之一.
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| 关 键 词： | 胃癌 人宫颈癌基因 Western印迹 免疫组化 |
Expression of HCCR in Human Gastric Carcinoma and its Clinical Significance |
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| ZHU min,DENG Chang-sheng,WANG Jun-wen. Expression of HCCR in Human Gastric Carcinoma and its Clinical Significance[J]. Chinese Journal of Clinical Gastroenterology, 2008, 20(6). DOI: 10.3870/j.issn.1005-541X.2008.06.014 |
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| Authors: | ZHU min DENG Chang-sheng WANG Jun-wen |
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| Affiliation: | ZHU min,DENG Chang-sheng,WANG Jun-wen Department of Gastroenterology,Zhongnan Hospital of Wuhan University,Wuhan,430071,China. |
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| Abstract: | Objective To investigate expression of human cerrical cancer oncogene(HCCR)in human gastric carcinoma and its clinical significance,we preliminary assessed the effect and significance of HCCR in human gastric carcinoma to search a new biomarker for it.MethodsHCCR protein expression in gastric carcinoma cells SGC-7901,BGC-823 were detected by Western blot,HCCR expression in 30 gastric carcinoma tissues and 10 normal para-cancer tissues was analyzed by immunohistochemistry.ResultsHCCR protein expression were ... |
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| Keywords: | Gastric carcinoma HCCR Western blot Immunohistochemistry |
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