| COX-2和VEGF-C基因在乳腺良恶性病变中的表达研究 |
| |
| 引用本文： | 肖锋,顾春燕,姚建国,陈咏梅,李民. COX-2和VEGF-C基因在乳腺良恶性病变中的表达研究[J]. 实用肿瘤杂志, 2011, 26(6): 573-576 |
| |
| 作者姓名： | 肖锋 顾春燕 姚建国 陈咏梅 李民 |
| |
| 作者单位： | 1. 南通大学附属南通第三医院病理科,江苏南通,226006
2. 南通市第二人民医院病理科,江苏南通,226002 |
| |
| 基金项目： | 南通市社会发展基金资助项目(S2008038) |
| |
| 摘 要： | 目的 研究COX-2和VEGF-C mRNA在乳腺良恶性病变中的表达情况,探讨两者在乳腺肿瘤发生过程中的相互关系.方法 运用Real-time PCR方法对90例乳腺良恶性病变组织中COX-2和VEGF-C mRNA的表达进行检测.结果 8例副乳腺组织中,COX-2和VEGF-C mRNA不表达或低表达,15例腺病和16例纤维腺瘤中两者表达明显增加(P＜0.05),11例DCIS中,两者均高表达,高于腺病和纤维腺瘤(P＜0.05),40例IDC中,两者同样高表达,并且肿瘤级别越高,表达水平越高.在DCIS和IDC中,两者表达存在正相关关系(分别r=0.82,P=0.002；r=0.89,P=0.000).结论 COX-2和VEGF-C基因在乳腺良恶性病变中表达明显增高,而且在恶性肿瘤中的表达高于良性肿瘤,两者在乳腺癌组织中的表达呈正相关,表明两者参与了乳腺疾病,尤其是乳腺癌发生、发展的过程.
|
| 关 键 词： | 乳腺肿瘤/病理学 环氧化酶2 血管内皮生长因子C RNA,信使 聚合酶链反应 基因表达 |
Expression of COX-2 and VEGF-C mRNA in benign and malignant breast diseases |
| |
| XIAO Feng,GU Chun-yan,YAO Jian-guo,et al. Expression of COX-2 and VEGF-C mRNA in benign and malignant breast diseases[J]. Journal of Practical Oncology, 2011, 26(6): 573-576 |
| |
| Authors: | XIAO Feng GU Chun-yan YAO Jian-guo et al |
| |
| Affiliation: | XIAO Feng,GU Chun-yan,YAO Jian-guo,et al(Department of Pathology,The Affiliated Third Hospital of Nantong University,Nantong,226006,China) |
| |
| Abstract: | Objective To investigate the expression of COX-2 and VEGF-C mRNA in benign and malignant breast diseases and their association with breast tumorigenesis.Methods Tissue specimens were collected from 8 cases of accessory breasts,15 cases of adenosis,16 cases of fibroadenoma,11 cases of ductal carcinoma in situ(DCIS) and 40 cases of invasive ductal carcinoma(IDC) .Real-time PCR was used to detect the expression of COX-2 and VEGF-C mRNA.Results The accessory breasts were all negative for COX-2 mRNA expression,a... |
| |
| Keywords: | breast neoplasms/pathology cyclooxygenase 2 vascular endothelial growth factor C RNA messenger polymerase chain reaction gene expression |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
