| FAT对K562和K562/A02细胞内药物积聚浓度的影响 |
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| 引用本文： | 张玉霞,梁琼.FAT对K562和K562/A02细胞内药物积聚浓度的影响[J].亚太传统医药,2012,8(1):9-10. |
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| 作者姓名： | 张玉霞 梁琼 |
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| 作者单位： | 1. 海南工商职业学院应用技术系,海南海口,570203
2. 海口经济学院工程技术学院,海南海口,570203 |
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| 摘 要： | 目的:寻找克服肿瘤细胞多药耐药的方法。方法:以FAT作为耐药逆转剂,采用流式细胞术,观察FAT对K562和K562/A02内药物的积聚和外排的影响。结果:FAT可增加K562/A02细胞内罗丹明123(Rhodamine 123)的含量,且存在剂量依赖关系,而对于K562细胞无明显影响。结论:FAT有望成为一种新型多药耐药逆转剂。
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| 关 键 词： | 白血病 FAT 多药耐药逆转 |
Effect of FAT on Intracellular Accumulation of Drug in K562/A02 Cells |
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| Zhang Yuxia,Liang Qiong.Effect of FAT on Intracellular Accumulation of Drug in K562/A02 Cells[J].Asia-Pacific Traditional Medicine,2012,8(1):9-10. |
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| Authors: | Zhang Yuxia Liang Qiong |
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| Institution: | 1.Department of Technology Application,Hainan Technology and Business College,Haikou 570203,China; 2.Department of Engineering Technology,Haikou College of Economics,Haikou 570203,China) |
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| Abstract: | Objective:To explore measures to overcome multidrug resistance of tumor cells.Methods:The effect of FAT on intracellular drug accumulation and drug efflux in K562 cell line and K562/A02 cell line was studied by flow cytometry.Results:FAT increased the intracellular Rho-123 concentration,the role of drug resistance reversal was FAT dose-dependant.The content of Rho-123 was not influenced by FAT in K562 cell line nearly.Conclusion:FAT is a novel multidrug resistance reversal agents. |
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| Keywords: | Leukemia FAT Reversal of Multidrug Resistance |
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