| 纳米粒子作为药物输送和药物控释体系的应用前景 |
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| 引用本文： | 杨菁,宋存先. 纳米粒子作为药物输送和药物控释体系的应用前景[J]. 基础医学与临床, 2006, 26(7): 684-688 |
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| 作者姓名： | 杨菁 宋存先 |
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| 作者单位： | 中国医学科学院中国协和医科大学,生物医学工程研究所,天津市生物材料重点实验室,天津,300192;中国医学科学院中国协和医科大学,生物医学工程研究所,天津市生物材料重点实验室,天津,300192 |
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| 基金项目： | 国家自然科学基金(50473059)，天津市应用基础重点项目(043803011)，博士学科点专项基金(20030023004)，天津市自然科学基金(05YFJMJC10100) |
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| 摘 要： | 纳米粒子作为药物和基因的载体显现出极大的潜力并被广泛研究。纳米粒子的超微小体积可使药物输送智能化,例如靶向定位地将药物投递到病灶局部或专一性地作用于靶细胞。纳米粒子的载体材料可屏蔽药物不良气味、维持药物长期缓慢释放、延长药物半衰期和减小毒副作用等。本文将从纳米药物输送、控释制剂的制备和应用前景等方面进行综述。
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| 关 键 词： | 纳米粒子 药物载体 基因载体 控制释放 |
| 文章编号： | 1001-6325(2006)07-0684-05 |
| 收稿时间： | 2006-04-12 |
| 修稿时间： | 2006-04-12 |
Perspective on the application of nanoparticules as drug delivery and control release systems |
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| YANG Jing,SONG Cun-xian. Perspective on the application of nanoparticules as drug delivery and control release systems[J]. Basic Medical Sciences and Clinics, 2006, 26(7): 684-688 |
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| Authors: | YANG Jing SONG Cun-xian |
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| Affiliation: | Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin 300192, China |
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| Abstract: | Nanoparticule (NP) as a drug and gene carrier has shown great potential and has been widely studied. Due to its ultra-small size, NP can achieve intelligent delivery of drugs, such as deliver drug site-specifically to disease focus or targeted tissue, even into target cells. The carrier materials of NPs provide it with such advantages as shielding odor, long-term sustained releasing of drug, lowering uoxicity,extend biologic half life of drug and gene, etc. This review emphasizes the manufacturing techniques and application of nanoparticles as drug and gene delivery system. |
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| Keywords: | nanoparticles drug delivery gene delivery controlled release |
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