Cervical sympathectomy affects adrenocorticotropic hormone and thyroid-stimulating hormone in rats |
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Authors: | Hiroshi Iwama Mamoru Adachi Choichiro Tase Yoichi Akama |
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Institution: | (1) Department of Anesthesiology, Fukushima Medical College, 1 Hikarigaoka, 960-12 Fukushima, Japan |
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Abstract: | To examine the effects of bilateral cervical sympathectomy on the secretion of adrenocorticotropic hormone (ACTH), thyroid-stimulating
hormone (TSH), growth hormone (GH), and prolactin (PRL), 18 male rats were divided into three groups: control (Cont), sham
operation (Sham), and bilateral cervical sympathectomy (Symp). All rats were kept under a normal circadian rhythm for 2 weeks.
Subsequently, blood was collected and plasma ACTH as well as serum TSH, GH, and PRL levels were measured. The difference in
ACTH levels between the Cont and Sham groups was not significant, but ACTH levels in the Symp group were significantly higher
than those in the other groups. The difference in TSH levels between the Cont and Sham groups was also not significant, but
TSH levels in the Symp group were significantly lower than those in the Cont group. There were no statistically significant
differences in GH and PRL levels among these groups. The present results suggest that cervical sympathectomy in the rat increases
ACTH secretion and decreases TSH secretion in the pituitary. These effects seem to be due to a mildly increased secretion
of melatonin in the pineal body that probably in turn increases corticotropin-releasing factor (CRF) secretion and decreases
thyrotropin-releasing hormone (TRH) secretion in the hypothalamus. Extrapolation of these findings to humans suggests that
longterm and repeated stellate ganglion block would affect the pituitary secretions of ACTH and TSH. |
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Keywords: | Cervical sympathectomy Stellate ganglion block Adrenocorticotropic hormone Thyroid-stimulating hormone Growth hormone Prolactin Rat |
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