酪氨酸激酶信号级联与支气管哮喘发病的关系

支气管哮喘的发病机制涉及炎症细胞和气道结构细胞、细胞因子、趋化因子、生长因子和炎症介质的相互作用.酪氨酸激酶信号级联在变应性气道炎症中起重要作用,活化的酪氨酸激酶激活了多重下游信号转导途径如磷酯酰肌醇3激酶、丝裂原活化蛋白激酶和核因子κB,导致细胞的分化、存活、增殖、脱颗粒和趋化.

Relationships between tyrosine kinase signaling cascade and bronchial asthma

The pathogenesis of bronchial asthma(asthma)involves the interplay of inflammatory cells and resident airway cells,and of their secreted mediators including cytokines,chemokines,growth factors and inflammatory mediators.Tyrosine kinase signaling cascades play a critical role in the pathogenesis of allergic airway inflammation.Activation of tyrosine kinases invokes multiple downstream signaling pathways,including PI3K,MAPK and NF-κB,leading to cell differentiation,survival,proliferation,degranulation and chemotaxis.