| 阴道念珠菌病小鼠模型中单核细胞趋化蛋白-1的表达及其意义 |
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| 引用本文： | 严小枫,李晖,林能兴,陈宏翔,黄长征,刘志香,邬炎卿,张德美,涂亚庭. 阴道念珠菌病小鼠模型中单核细胞趋化蛋白-1的表达及其意义[J]. 中国皮肤性病学杂志, 2006, 20(11): 662-665 |
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| 作者姓名： | 严小枫 李晖 林能兴 陈宏翔 黄长征 刘志香 邬炎卿 张德美 涂亚庭 |
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| 作者单位： | 1. 华中科技大学同济医学院附属协和医院皮肤科,湖北,武汉,430022
2. 宜昌市第二人民医院皮肤科,湖北,宜昌,443000 |
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| 摘 要： | 目的检测阴道念珠菌病小鼠模型中单核细胞趋化蛋白-1(MCP-1)的表达,并对其在阴道念珠菌病发病中的作用进行探讨。方法建立阴道念珠菌病小鼠模型,以免疫组化染色SABC法检测小鼠阴道黏膜中MCP-1蛋白的表达,并应用HMIAS-2000型全自动医学彩色图像分析系统对小鼠阴道黏膜MCP-1的表达进行半定量分析。结果与对照组及正常小鼠相比,感染组小鼠阴道黏膜MCP-1表达水平明显升高,且随时间延长逐渐升高,14天达到高峰,第21天略有下降。结论MCP-1可能在局部阴道黏膜内对白念珠菌的感染起一定的防御作用。
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| 关 键 词： | 念珠菌病,外阴阴道 白念珠菌 单核细胞趋化蛋白质1 |
| 文章编号： | 1001-7089（2006）11-0662-03 |
| 收稿时间： | 2006-01-29 |
| 修稿时间： | 2006-01-29 |
Expression of MCP-1 in Mice with Experimental Vaginal Candidiasis and Potential Significance |
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| YAN Xiao-feng, LI Hui,LIN Neng-xing,et al. Expression of MCP-1 in Mice with Experimental Vaginal Candidiasis and Potential Significance[J]. The Chinese Journal of Dermatovenereology, 2006, 20(11): 662-665 |
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| Authors: | YAN Xiao-feng LI Hui LIN Neng-xing et al |
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| Affiliation: | Department of Dermatology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Objective To investigate the role of MCP-1 during a Candida albicans vaginal infection by detecting its expression in mice with experimental vaginal candidiasis. Methods To set up a murine model of vaginal candidiasis,and to detect the expression of MCP-1 in vaginal tissue by immunohistochemistry.Semi-quantitative measurement of MCP-1 expression in vaginal tissue was done with High Multiply Image Analytical System (HMIAS).Results The expression of MCP-1 in vaginal tissue of infected mice was significantly higher than those in controls and normal mice.As time going on,the expression of MCP-1 increased,and reached its climax at day 14,than declined a little on day 21.Conclusion MCP-1 may play a role in the local vaginal mucosal response to C.albicans. |
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| Keywords: | Candidiasis, vulvovaginal Candida albicans Monocyte chemoattractant protein-1 |
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