| 榼藤子含硫酰胺类化学成分的研究(英文) |
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| 作者姓名： | Xiong H Xiao E Zhao YH Yang GZ Mei ZN |
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| 作者单位： | 中南民族大学药学院;西双版纳州民族医药研究所; |
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| 基金项目： | Project supported by the 11th Five-year Plan of Ministry of Science and Technology of the People's Republic of China (No.2007BAI48B08) |
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| 摘 要： | 为研究榼藤子Entada phaseoloides(L.)Merr.]种仁的化学成分,利用正反相硅胶柱色谱、制备HPLC分离纯化,通过现代波谱学技术鉴定结构。从70%乙醇提取物的正丁醇萃取部位分离得到4个含硫酰胺类化合物,分别为entadamideA-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside(1)、entadamideA(2)、entadamideA-β-D-glucopyranoside(3)和clinacosideC(4)。化合物1为新化合物,化合物4为首次从该属中分离得到。
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| 关 键 词： | 榼藤子 化学成分 含硫酰胺 |
Sulfur-containing amides from Entada phaseoloides |
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| Xiong H,Xiao E,Zhao YH,Yang GZ,Mei ZN.Sulfur-containing amides from Entada phaseoloides[J].Acta Pharmaceutica Sinica,2010,45(5):624-626. |
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| Authors: | Xiong Hui Xiao Er Zhao Ying-Hong Yang Guang-Zhong Mei Zhi-Nan |
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| Institution: | XIONG Hui1,XIAO Er1,ZHAO Ying-hong2,YANG Guang-zhong1,MEI Zhi-nan1 (1.College of Pharmacy,South-Central University for Nationalities,Wuhan 430074,China,2.Institute of National Medicine of Xishuangbanna,Xishuangbanna 666100,China) |
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| Abstract: | To study the chemical constituents of the Entada phaseoloides (L.) Merr., seeds of Entada phaseoloides were extracted with 70% ethanol at room temperature. Isolation and purification were performed by silica gel, reversed-phase silica gel column chromatography and semi-preparative HPLC. Structures of the pure compounds were established on the basis of spectral analysis. Four sulfur-containing amide compounds were isolated from the n-BuOH-soluble fraction and identified as entadamide A-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranoside (1), entadamide A (2), entadamide A-beta-D-glucopyranoside (3) and clinacoside C (4). Compound 1 is a new compound. Compound 4 is isolated from the genus Entada for the first time. |
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| Keywords: | Entada phaseoloides chemical constituent sulfur-containing amide |
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