Brg1在喉鳞状细胞癌组织中的表达及意义

目的：研究Brg1在喉鳞状细胞癌（LSCC）组织中的表达，探讨其与喉癌发生发展的关系。方法：应用免疫组织化学技术分析30例LSCC及10例癌旁正常黏膜中Brg1的表达情况。 结果：Brg1在癌旁正常黏膜中阳性表达（灰度值为124.60±4.51），LSCC组织中表达降低（灰度值为159.20±7.69），两组比较差异有显著性（P<0.01）。Brg1在高、中、低分化LSCC组织中表达灰度值分别为132.80±1.92、165.20±2.59和179.60±1.52，高分化LSCC与中分化、低分化LSCC比较差异有显著性（P<0.01）；Brg1在Ⅰ-Ⅱ期、Ⅲ 期、Ⅳ期LSCC表达的灰度值分别为145.30±2.36、165.20±4.31和179.40±3.03，Ⅲ期、Ⅳ期分别与Ⅰ-Ⅱ期比较差异有显著性（P<0.05）。Brg1在有脉管侵润组和无脉管侵润组表达灰度值分别为176.80±3.48和143.50±8.26，两组比较差异有显著性（P<0.01）。Brg1在有淋巴结转移组和无淋巴结转移组表达灰度值为155.60±4.02和161.70±3.52，两组比较差异无显著性（P>0.05）。结论：Brg1在LSCC中表达低，并与其发展及病理因素有关，可能是LSCC发生的一个重要因素。

Expression of Brg1 in laryngeal squamous cell carcinoma tissue and significance

Objective To study the expression of Brg1 in laryngeal squamous cell carcinoma (LSCC) tissue and explore its relationship with the occurrence and development of laryngeal cancer. Methods Immunohistochemical method was used to detect the expressions of Brg1 in 30 cases of LSCC and 10 cases of paracarcinoma normal mucosa. Results The expression of Brg1 in paracarcinoma normal mucosa was positive(the grey value was 124.60±4.51),and the expression of Brg1 in LSCC was low(the grey value was 159.20±7.69),the difference between two groups was significant(P<0.01). The grey values expressed by Brg1 in well,moderately and poorly differentiated LSCC were 132.80±1.92,165.20±2.59,and 179.60±1.52,respectively;there were significant differences betwen moderately,poorly differentiated LSCC and well differentiated LSCC (P<0.01). The grey values expressed by Brg1 in stage Ⅰ-Ⅱ,stage Ⅲ and stage Ⅳ LSCC were 145.30±2.36,165.20±4.31,and 179.4±3.03,respectively;there were significant differences between stage Ⅲ,stage Ⅳ and stage Ⅰ-Ⅱ (P<0.05).The grey values expressed by Brg1 in vascular invasion group and no vascular invasion group were 176.80±3.48 and 143.50±8.26,the difference between two groups was significant(P<0.01). The grey values expressed by Brg1 in lymph node metastasis group and no lymph node metastasis group were 155.60±4.02 and 161.70±3.52,there was no significant difference between two groups(P>0.05). Conclusion The expression of Brg1 in LSCC is low,and it is related to the development of cancer and pathological factors,which may be an important factor in laryngeal cancer.