小儿病毒性心肌炎的免疫改变观察

为探讨免疫与小儿病毒性心肌炎发病的关系，检测５４例病毒性心肌炎血清免疫球蛋白和外周血Ｔ淋巴细胞亚群，与健康对照组对比，结果：病毒性心肌炎急性期，恢复期血清免疫球蛋白无明显变化，急性期ＣＤ３、ＣＤ４和ＣＤ４／ＣＤ８均明显下降，恢复期ＣＤ８下降，ＣＤ４／ＣＤ８明显升高；１３例慢性期ＣＤ８进一步下降，ＣＤ４／ＣＤ８进一步升高，提示病毒性心肌炎的免疫改变以细胞免疫为主，存在细胞免疫功能紊乱，急性期细胞免疫功能低下，恢复期、慢性期存在免疫过强和自身免疫反应。

Immunological changes of viral myocarditis in children

To explore the immunological changes of viral myocarditis in children, serum immunoglobulin and peripheral T lymphocyte subgroup were measured in 54 children with viral myocarditis and 48 normal controls, respectively. The results showed that no significant change of immunoglobulin was observed either in acute stage or in convalescent stage. It was found that the percentages of CD3 and CD4 T cells and the ratio of CD4 and CD8 decreased significantly in acute stage while the percentage of CD8 T cell decreased and the ratio of CD4 and CD8 increased obviously in convalescent stage. It was further found that the percentage of CD8 T cell advanced decreased and the ratio of CD4 and CD8 advanced increased in 13 cases during their chronic stage. It is suggested that cell immune play an important role in the pathogenesis of the viral myocarditis. It is obvious that the cell immune represents hypofunction in acute stage and hyperfunction with an autoimmune reaction in either convalescent stage or chronic stage.