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缺血性卒中后血浆超敏C-反应蛋白和白介素-6的早期动态变化与临床表现的关系探讨
引用本文:马越涛,刘丽萍,王拥军. 缺血性卒中后血浆超敏C-反应蛋白和白介素-6的早期动态变化与临床表现的关系探讨[J]. 中国卒中杂志, 2011, 6(4): 268-274
作者姓名:马越涛  刘丽萍  王拥军
作者单位:首都医科大学附属北京天坛医院神经内科
摘    要:目的 观察急性缺血性卒中患者发病后早期血浆超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)及白介素-6(interleukin-6,IL-6)水平的动态变化规律,探讨其与卒中患者临床表现及预后的关系。方法 连续入选急性缺血性卒中患者47例,正常对照组40例,比较卒中组发病后系列时间点血浆hs-CRP和IL-6水平与正常对照组之间的差异,分析其动态变化规律;按照基线美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分将患者分为轻型组(n=15)和重型组(n=32),比较两组血浆hs-CRP和IL-6水平;并比较不同临床预后患者血浆hs-CRP和IL-6水平的差异。结果 卒中组发病3h时血浆hs-CRP较对照组差异无统计学意义,6 h、12 h、24 h、48 h、3 d及7 d血浆hs-CRP较对照组明显升高(均P ≤0.01)。卒中组各时间点血浆IL-6水平均高于正常对照组(均P <0.01)。重型组血浆hs-CRP水平在12 h、24 h、48 h、3 d及7 d时水平均高于轻型组(P =0.046,0.012,0.030,0.007,0.041);重型组血浆I L-6水平在12 h、24 h、48 h、3 d及7 d时水平均高于轻型组(P =0.002,0.001,0.006,0.026,0.043)。不同预后组之间血浆hs-CRP和IL-6水平差异不明显。结论 急性缺血性卒中患者血浆hs-CRP和IL-6水平升高,且与临床严重程度有关。

关 键 词:脑梗死  C反应蛋白质  白细胞介素6  
收稿时间:2010-11-11

Early Time Course of Serum High Sensitive C-reactive Protein and interleukin-6 after Acute Ischemic Stroke
MA Yue-Tao,LIU Li-Ping,WANG Yong-Jun. Early Time Course of Serum High Sensitive C-reactive Protein and interleukin-6 after Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2011, 6(4): 268-274
Authors:MA Yue-Tao  LIU Li-Ping  WANG Yong-Jun
Affiliation:. Department of Neurology, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing 100050, China
Abstract:Objective To investigate the early time course of plasma high sensitive C-reactive protein (hs- CRP) and interleukin-6 (IL-6) level after acute ischemic stroke and the relationship with clinical characters and outcome. Methods Serial enrollment of acute ischemic stroke patients (n=47) and healthy controls (n=40). We compared the serial measurements of plasma hs-CRP and IL-6 level of acute ischemic stroke patients with that of healthy controls, and analyzed their dynamic variation rules. Patients were divided into mild stroke (n-15) and severe stroke (n=32) group according to national institutes of health stroke scale (NIFISS). We compared the plasma level of hs-CRP and IL-6 of the two groups, and also that of the patients with good and poor outcome. Results There was no difference of plasma hs-CRP at 3h between stroke patients and healthy controls, but was significantly higher in stroke patients at 6h (P=0.01), 12h (P=0.01), 24h (P〈0.01), 48h (P〈0.01), 3d (P〈0,01) and 7d (P〈0.01) than controls. Plasma IL-6 of stroke patients at each time points was significantly higher than that of the controls (P〈0.01). Hs-CRP level of severe stroke patients was significantly higher than mild ones at 12h, 24h, 48h, 3d and 7d (p=-0.046, 0.012, 0.030, 0.007 and 0.041, respectively). The same was also true for IL-6 at those time points (P=0.002, 0.001, 0.006, 0.026 and 0.043, respectively). There was no difference of plasma hs-CRP and IL-6 level between patients with good and poor outcome.Conclusion Plasma hs-CRP and IL-6 levels elevated after acute ischemic stroke, and correlated with clinical severity.
Keywords:Brain infarction  C-reactive protein  lnterleukin-6
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