纤维蛋白原对肝移植术后患者凝血功能的影响

目的观察纤维蛋白原对肝移植术后患者凝血功能的影响。方法将26例肝移植患者分成治疗组与对照组,治疗组术中、术后间断应用纤维蛋白原,而对照组只在术中使用;分别于新肝灌注0.5h,术后24.0h及72.0h采静脉血检测两组患者凝血酶原时间(PT),纤维蛋白原(Fib)和激活的部分凝血活酶时间(APTT)。结果行肝移植术后伴有低纤维蛋白原血症且PT、APTT延长的患者,应用纤维蛋白原能够使PT、APTT时间缩短,与对照组间差别有显著性意义(P<0.05)。结论肝移植患者术后在补充血浆、血小板、凝血酶的同时,补充纤维蛋白原有利于改善肝移植术后凝血功能的异常。

The Influence of Fibrinogen on Coagulant Function after Liver Transplantation

Objective To observe the effect of additional fibrinogen on coagulant function of patients after liver transplantation.Methods 26 patients underwent orthotropic liver transplantation(OLT)were randomly divided into two groups:the therapeutic group and the controlled group.The additional fibrinogen was used during and after the operation in the former group,but in the latter group it was used only during the operation.Prothrombin time (PT),active partial thromboplastic time (APTT) and fibrinogen (Fib) were measured 0.5 h after the new liver reperfusion and post-operative 24 h and 72 h of OLT respectively.Results Using fibrinogen could shorten the time of PT or APTT for patients who underwent liver transplantation with lower fibrinogen and longer PT and APTT.The level of PT and APTT in the therapeutic group significantly different from that in the controlled group (P<0.05).Conclusion Adding fibrinogen is good for improving the recovery of coagulation function,as well as adding platelet,plasma and other coagulation factors after liver transplantation.