Comparative study of dose distribution between carbon ion radiotherapy and photon radiotherapy for head and neck tumor |
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Authors: | Amirul Islam M Yanagi Takeshi Mizoe Jun-Etsu Mizuno Hideyuki Tsujii Hirohiko |
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Institution: | RNPD, INST, Atomic Energy Research Establishment, Ganakbari, Savar, Dhaka, 1349, Bangladesh. liton80m@yahoo.com |
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Abstract: | PURPOSE: A comparative treatment planning study has been performed between carbon ion radiotherapy (CIRT) and photon radiotherapy three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT)] to assess the potential improvements and limitations that could result for locally advanced, nonresectable head and neck tumors. MATERIALS AND METHODS: Seven patients, originally treated with CIRT, were randomly selected for the comparative study. The evaluations analyzed using dose-volume histogram parameters, conformity index, inhomogeneity coefficient, and dose to the organs at risk (OARs). RESULTS: The mean conformity index was 1.46, 1.43, and 1.22 for 3D-CRT, IMRT, and CIRT, respectively. The mean inhomogeneity coefficient was 0.05, 0.07, and 0.02 for 3D-CRT, IMRT, and CIRT respectively. Photon plans resulted in greater volumes of normal tissues at 10% to 95% isodose levels compared with the corresponding carbon ion plans where the volumes increased by a factor of 1.2 to 2.7 for 3D-CRT and 1.2 to 2.0 for IMRT. CONCLUSION: CIRT has the potential to improve the target dose conformity, inhomogeneity coefficient, and OAR sparing when compared with 3D-CRT and IMRT. Compared with 3D-CRT, normal tissue exposure was reduced mainly in the mid-to low-isodose levels using IMRT. Additional improvement was obtained using CIRT. |
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Keywords: | Comparative study Dose distribution Carbon ion radiotherapy Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy |
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