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胃间质瘤组织FAP的表达及其与预后的相关性分析
引用本文:汤苏敏,沈朝勇,尹 源,等. 胃间质瘤组织FAP的表达及其与预后的相关性分析[J]. 四川大学学报(医学版), 2017, 48(2): 234-238
作者姓名:汤苏敏  沈朝勇  尹 源  
作者单位:1.四川大学华西医院胃肠外科
摘    要:【摘要】 目的 探讨胃间质瘤(GSTs)组织中成纤维细胞活化蛋白(FAP)的表达情况及其与预后的相关性。方法 收集2010年1月至2013年12月间我院病理科保存的GSTs石蜡标本,通过免疫组化染色检测FAP表达;另取GSTs高、低恶性度患者新鲜肿瘤组织,进行FAP蛋白芯片分析,分析FAP与肿瘤临床病理特点及患者预后间的关系。结果 本研究共纳入98例符合标准的病例,通过免疫组化染色显示FAP表达于GSTs细胞的胞浆,阳性表达率为42.9%,在正常胃组织中不表达。在不同性别、年龄及核分裂象数的患者中,FAP表达差异无统计学意义(P 均>0.05);而在不同肿瘤长径和危险度分级患者中,FAP表达差异有统计学意义(P 均<0.05),长径较大和中高危险度分级的肿瘤,FAP阳性表达率更高。FAP蛋白芯片分析结果显示,高恶性度GSTs组织中FAP表达量较在低恶性度GSTs组织的表达上调8.4倍。FAP表达与常规免疫组化指标之间无明显关联性。生存分析示:核分裂象数、肿瘤长径、术后服用伊马替尼(IM)及FAP表达,影响中高危GSTs患者无复发累积生存率(RFS)(P 均<0.05)。Cox多因素回归示:核分裂象数、肿瘤长径、术后服用IM及FAP表达,是影响中高危GSTs患者RFS的独立因素(P 均<0.05)。结论 FAP表达于GSTs细胞的胞浆,而在正常胃组织中不表达。FAP可辅助评估中高危GSTs患者的预后。

关 键 词:胃间质瘤 FAP 预后

FAP Expression and Its Association with the Prognosis of Gastric Stromal Tumors
TANG Su-min,SHEN Chao-yong,YIN Yuan,et al. FAP Expression and Its Association with the Prognosis of Gastric Stromal Tumors[J]. Journal of Sichuan University. Medical science edition, 2017, 48(2): 234-238
Authors:TANG Su-min  SHEN Chao-yong  YIN Yuan  et al
Abstract:【Abstract】 Objective To determine the association of FAP expression with the prognosis of gastric stromal tumors (GSTs). Methods Paraffin-embedded GSTs samples were collected from January 2010 to December 2013 in the department of pathology of our hospital. FAP expression was examined by immunohistochemistry staining. Its correlations with clinical pathological characteristics and prognosis of GSTs were analyzed. Results A total of 98 cases were included in this study. FAP was expressed in the cytoplasm of GSTs cells, with a positive rate of 42.9%. No FAP expression was found in normal gastric tissues. No differences of FAP expression were found in patients with different gender, age and tumor mitotic counts (P >0.05). Tumor diameter and risk classification were associated with FAP expression (P <0.05). Higher levels of FAP expression were found in larger and higher risk tumors. No significant correlations between FAP expression and routine immunohistochemical markers were found. Log-rank univariate survival analysis showed that mitotic counts, tumor size, postoperative IM and FAP expression were associated with recurrence free survival of GSTs patients with intermediate-high risks (P <0.05). Cox multivariate survival analysis showed that mitotic counts, tumor size, postoperative IM and FAP were independent predictors for the prognosis of GSTs patients with intermediate-high risks (P <0.05). Conclusion FAP is expressed in the cytoplasm of gastric GIST cells, but not in normal gastric tissues. FAP is a predictor for the prognosis of GSTs patients with intermediate-high risks.
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