草酸铂联合氟尿嘧啶和亚叶酸钙治疗晚期大肠癌36例临床观察

目的 观察草酸铂(L-OHP)联合氟尿嘧啶(5-Fu)和亚叶酸钙(CF)治疗晚期大肠癌的近期疗效和毒副反应.方法 经病理组织学诊断的晚期大肠癌36例,用L-OHP 130 mg/m2,静脉滴注4h,每天1次;CF 200 mg,静脉滴注2 d,继以5-Fu 400 mg/m2,dl,d2,静脉滴入,5-Fu600 mg/m2,微量泵入A48 h以上,每3周重复1次,作为1个治疗周期,治疗2个周期后评定疗效.结果 36例总有效率为13例(37.1﹪),完全缓解1例(2.8﹪),部分缓解12例(33.3﹪),无变化14例(38.9﹪),进展9例(25﹪).主要的毒副作用为神经毒性、骨髓抑制、恶心呕吐等,无治疗相关性死亡患者.结论 L-OHP联合大剂量CF及5-Fu治疗晚期大肠癌疗效较好,毒副反应能为患者耐受,值得临床推广应用.

Clinical observation on drug combination of oxaliplatin(L-OHP),fluorouracil(5-Fu)and calcium folinate(CF)in treatment of advanced colorectal cancer

Objective To study the recently curative,noxious and side effect of drug combina- tion of oxaliplatin (L-OHP),fluorouracil (5-Fu) and calcium folinate (CF) in the cure of coloreetal canc- er in advanced stage.Methods 36 cases of colorectal cancer in advanced stage diagnosed by pathology was involved.L-OHP 130 mg/m~2 was injected in 4 hours in dl,CF 200 mg was inject in first two days, followed by the injection of 5-Fu 400 mg/~m2 in dl,2,and the micro pumping of 5 - Fu 600 mg/m~2 over 48 hours in d2.The treatment was repeated every three weeks as one cycle and the curative effect was e- valuated after 2 cycles.Results The total effective rate of the 36 cases was 37.1% (13cases),the com- plete remission(CR) was lcase(2.8%),the partial remission was 12cases(33.3%),no changed was 14 cases(38.9%) and progression was 9 cases(25%).The main noxious and side effects were neurotox- ieity,myelosuppression,nausea and vomiting,etc.There was no cure related death.Conclusion The curative effect of drug combination of oxaliplatin(L-OHP),fluorouracil(5-Fu) and calcium folinate(CF) in the cure of colorectal cancer was good and the noxious and side effect was tolerable,meanwhile the combination was worth to be used widely.