| Abstract: | Summary: The excretion of nalidixic acid (α 1, 8, naphthyridine) has been studied in patients with renal impairment. The clearance of the therapeutically active naphthyridines was not related to renal function. The clearance of inactive conjugates of nalidixic acid was decreased in patients with renal failure resulting in a rise in plasma levels during continuous therapy. Despite severe renal failure therapeutic levels of active naphthyridines in the urine were usually obtained. Sodium bicarbonate administered orally in conjunction with nalidixic acid appeared to increase the absorption and the urinary clearance of the active naphthyridines. |
