妊娠期肝内胆汁淤积症118例临床分析

目的探讨妊娠期肝内胆汁淤积症（ICP）的发生率、诊断及处理。方法对本院近8年发生的118例ICP病例分治疗组（70例）和对照组（48例）资料进行回顾性分析。结果治疗组围产儿死亡率，宫内窘迫，新生儿窒息发生率明显少于对照组，差异具有显著性（P〈0．01）。结论对ICP的早期诊断、早期治疗，适时终止妊娠是降低围产儿死亡率的关键，也可降低产后出血的发生率。

Clinical analysis of 118 cases with intrahepatic cholestasis of pregnancy

Objective To discuss the incidence,diagnosis and management of intrahepatic cholestasis of pregnancy（ICP）. Methods 118 cases with ICP in our hospital for nearly 8 years,70 in the treatment groups and 48 in the non - treatment groups,were analyzed retrospectively. Resuits In treatment groups ,the incidence of perinatal mortality, fetal distress and asphyxia of newborn infants were significantly lower than those in contral groups（ P 〈 0.01 ）. Conclusion To diagnose and treat ICP early, appropriate opportunity for delivery is cardinal procedure to reduce perinatal mortality and postpartum hemorrhage.