| 脑内五羟色胺与干扰素镇痛 |
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| 引用本文： | 唐毓环,孙国光,王绍,房家智,夏映红. 脑内五羟色胺与干扰素镇痛[J]. 吉林大学学报(医学版), 1986, 0(1) |
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| 作者姓名： | 唐毓环 孙国光 王绍 房家智 夏映红 |
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| 作者单位： | 白求恩医科大学生化教研室(唐毓环，孙国光)，白求恩医科大学生理教研室(王绍，房家智)，白求恩医科大学生理教研室(夏映红) |
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| 摘 要： | 由侧脑室或在中脑导水管周围灰质内微量注射入白细胞α-干扰素可以引起大鼠痛阈明显上升,但脑内5-HT和5-HIAA均无变化。看来干扰素的镇痛作用和脑内5-HT递质无关,它可能是不经过5-HT的释放也不和吗啡受体结合起作用的另一类型的镇痛物质。
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| 关 键 词： | 五羟色胺 五羟吲哚乙酸 痛阈 中脑导水管周围灰质 |
Serotonin in brain and the analgesic action of interferon |
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| Tang Yuhuan,Wang shao,Sun kuoguang,Fang Jiazhi and Xia Yinghong. Serotonin in brain and the analgesic action of interferon[J]. Journal of Jilin University: Med Ed, 1986, 0(1) |
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| Authors: | Tang Yuhuan Wang shao Sun kuoguang Fang Jiazhi Xia Yinghong |
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| Abstract: | Microinjection of α-interferon into lateral ventricles or periaqueductal grey matter might induce marked increase in the pain threshold in rats. But the concentrations of 5-HT and 5-HIAA in telencephalon and brainstem did not show any change, and only in diencephalon the 5-HT obviously decreased. It showed that the analgesic action of interferon was not concerned with the concentration of 5-HT in brain.It is probably that interferon belongs to another kind of analgesics, exerting its effect not through the process of releasing 5-HT or combining with opiate receptors. |
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| Keywords: | Serotonin 5-hydroxyindole acetic acid Pain threshold Midbrain periaqueductal grey matter |
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