大黄联合血液净化治疗马蜂蜇伤并多脏器功能障碍的疗效观察

目的:观察大黄联合血液净化治疗马蜂蛰伤并发多脏器功能障碍(MODS)的疗效。方法:选取病历资料完整的马蜂蜇伤并发MODS且急性肾损伤(AKI)Ⅱ期以上患者89例,按随机数字表法分为血液净化联合大黄组(治疗组)和单独血液净化组(对照组),观察两组患者治疗前后血尿素氮、血肌酐、N-乙酰-β-d氨基葡萄糖、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、直接胆红素、肌酸激酶水平,心电图异常者例数,少尿期时间,住院时间,血液净化次数及疗效。结果:两组患者心电图异常者例数与治疗前比较,差异具有统计学意义(P>0.05);治疗组与对照组的少尿期时间、住院时间、血液净化次数及疗效比较,差异具有统计学意义(P<0.05)。结论:大黄联合血液净化治疗马蜂蛰伤并发MODS的疗效优于单独血液净化治疗。

Efficacy Observation of Rheum palmatum Combined with Blood Purification for Hornet Stings and Multiple Organ Dysfunction Syndrome

OBJECTIVE：To observe therapeutic efficacy of Rheum palmatum combined with blood purification for hornet stings and multiple organ dysfunction syndrome（MODS）. METHODS：89 patients with hornet stings,MODS and above Ⅱ stage acute kidney injury（AKI）were randomly divided into blood purification combined with R. palmatum group（treatment group）and blood purification group（control group）. BUN,Scr,N-acetyl-β-d glucosamine,glutamic-pyruvic transaminase,GOT,TBIL,DBIL,creatine kinase,electrocardiogram,oliguria stage,length of stay,the times of blood purification and the improvement of organs were observed in 2 groups. RESULTS：There was statistical significance in electrocardiogram of 2 groups before and after treatment（P〈0.05）. There was statistical significance in oliguria stage,length of stay,the times of blood purification and therapeutic efficacy between 2 groups（P〈0.05）. CONCLUSIONS：R. palmatum combined with blood purification is better than blood purification alone in the treatment of hornet stings and MODS.