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Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest |
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| Authors: | Michael B Ujiki Xian-Zhong Ding M Reza Salabat David J Bentrem Laleh Golkar Ben Milam Mark S Talamonti Richard H Bell Takeshi Iwamura Thomas E Adrian |
| Affiliation: | (1) Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA;(2) Department of Surgery, Miyazaki University School of Medicine, Miyazaki, Japan;(3) Department of Physiology, United Arab Emirates University, Al Ain, UAE |
| Abstract: | BackgroundMany chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been studied in pancreatic cancer. We hypothesized that apigenin would inhibit pancreatic cancer cell growth in vitro. |
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