Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer |
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| Authors: | Philippe Leissner Thibault Verjat Thomas Bachelot Malick Paye Alexander Krause Alain Puisieux Bruno Mougin |
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| Affiliation: | (1) Oncology & Human Genetics Department, bioMrieux SA, F-38024 Grenoble, France;(2) Centre Lon Brard, F-69008 Lyon, France;(3) INSERM U590, Centre Lon Brard, F-69008 Lyon, France |
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| Abstract: | Background One of the most thoroughly studied systems in relation to its prognostic relevance in patients with breast cancer, is the plasminogen activation system that comprises of, among others, the urokinase Plasminogen Activator (uPA) and its main inhibitor, the Plasminogen Activator Inhibitor-1 (PAI-1). In this study, we investigated the prognostic value of uPA and PAI-1 at the mRNA level in lymph node- and hormone receptor-positive breast cancer. |
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