氯丙嗪对精神分裂症患者血液流变学及血小板聚集的影响

为探讨氯丙嗪对精神分裂症（ＳＰ）患者血液流变学及血小板聚集功能的影响，对５０例患者于氯丙嗪治疗前后作简明精神病量表（ＢＰＲＳ）评定及血液流变学和血小板聚集功能测定并与对照组比较。结果：ＳＰ患者治疗前全血表观高、中、及低切粘度，红细胞压积，纤维蛋白原浓度、红细胞电泳时间，血小板１ｍｉｎ，５ｍｉｎ和最大聚集率显著高于对照组（Ｐ〈０．０１），血沉和血浆粘度与对照组比较差异无显著性（Ｐ〉０．０５）；氯丙嗪

The Effect of Chlorpromazine on Blood Rheology and Platelet Aggregating Function in Schizophrenics

The effect of chlorpromazine on blood rheology and platelet aggregating function in schizophrenics was investigated. The BPRS's evaluation and the measures of both the blood rheology and platelet aggregating function were conducted in 50 patients with schizophrenics and compared with control group before and after chlorpromazine treatment. Results showed the high shear (200 s 1 ), middle shear (30 s 1 ) and low shear (3 s 1 ) of whole blood apparent viscosity, the Hct, the level of fibrinogen, the time of erythrocyte electrophoresis, PAR1, PAR5 and PARm were all increased ( P <0 01), but ESR and plasma viscosity had no significant change before treatment in schizophrenia ( P >0 05) as compared with those in the control group. After one month of treatment, the score of BPRS was decreased ( P <0 01), but the 200 s 1 , 30 s 1 and 3 s 1 viscosity, the Hct, the Fg and the time of erythrocyte electrophoresis were all obviously decreased ( P <0 01, 0 05). No significant changes in the plasma viscosity, the ESR and platelet PAR were found. PAR5 and PARm were obviously enhanced ( P <0 01). It was suggested that the chlorpromazine treatment cough improve the high viscosity state of blood rheology and enhance platelet endogenous aggregating function.