Evaluation of equilibrium dialysis volume shifts: A comment |
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Authors: | Stephen H. Curry Oliver Y. -P. Hu |
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Affiliation: | (1) Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, 32610 Gainesville, FL |
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Abstract: | Previous authors have presented in this journal an equation defining the fractional shift in volume (fs)as a general equation implying applicability to a wide variety of circumstances. The equation concerned actually applies only when the starting volumes before dialysis are equal. A better general definition is given by fs=(volume shift)/(starting volume of protein solution). |
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Keywords: | equilibrium dialysis volume shift protein binding |
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