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Evaluation of equilibrium dialysis volume shifts: A comment
Authors:Stephen H. Curry  Oliver Y. -P. Hu
Affiliation:(1) Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, 32610 Gainesville, FL
Abstract:Previous authors have presented in this journal an equation defining the fractional shift in volume (fs)as a general equation implying applicability to a wide variety of circumstances. The equation concerned actually applies only when the starting volumes before dialysis are equal. A better general definition is given by fs=(volume shift)/(starting volume of protein solution).
Keywords:equilibrium dialysis  volume shift  protein binding
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