积雪草提取物对胃粘膜的保护作用及其机制探讨

目的观察积雪草提取物（ＴＣＡ）对胃粘膜损伤的防治作用及其可能的机制。方法采用大鼠胃损伤模型，测定损伤指数、髓过氧化物酶（ＭＰＯ）、丙二醛（ＭＤＡ）、细胞因子、胃粘膜细胞存活率等。结果（１）ＴＣＡ对乙醇胃粘膜损伤具有预防作用；（２）对乙酸胃溃疡具有治疗作用；（３）可以降低ＭＰＯ、ＭＤＡ、ＩＬ８的产生；（４）可以增加胃粘膜细胞的存活率。结论（１）ＴＣＡ对胃粘膜损伤有防治作用；（２）ＴＣＡ降低血管的通透性及减少ＭＰＯ、ＭＤＡ、ＩＬ８；（３）对胃粘膜细胞的直接保护作用可能是其作用机制之一。

Protection of titracted extract of centella asiatica on gastric mucosa and its possible mechanism

Objective To study the gastric mucosal protective effect of titracted extract of centella asiatica (TCA) and its possible mechanism in rats. Methods To adopt gastric damage models in rats; detect damage index; myloperoxidase (MPO); malonaldehyde (MDA); cytokines; gastric mucosal cell viability etc. Results (1)TCA could prevent gastric mucosal damage from ethanol; (2) TCA could exert therapeutic effect on gastric ulcer induced by acetic acid; (3) MPO, MDA, IL8 were all decreased and gastric mucosal cell viability increased. Conclusion (1)TCA has preventive and therapeutic effects on gastric mucosal injury; (2) TCA reduces vascular permeability MPO, MDA and IL8; (3)TCA has direct protective effect on gastric mucosal cell, one of its mechanism may be cytoprotection.