Response to vecuronium in a patient with facioscapulohumeral muscular dystrophy |
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Authors: | Nitahara K Sakuragi T Matsuyama M Dan K |
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Institution: | Department of Anesthesiology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan |
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Abstract: | Increased sensitivity to vecuronium has been noted in patients with
Duchenne muscular dystrophy. We report the response to vecuronium in a
patient with facioscapulohumeral muscular dystrophy (FSHD), an autosomal
dominant disorder with an incidence of 10-20 cases per million. In this
patient, sensitivity to an initial dose of vecuronium (0.02 + 0.08 mg kg-1)
was normal, but recovery was faster and the effect of incremental doses of
vecuronium (0.02 mg kg-1) was less than expected. Onset time and 25%
recovery of T1/T0 after the intubating dose of vecuronium were 240 s and 22
min, respectively. Recovery index (spontaneous recovery of T1/T0 from 25%
to 75%) was 9 min.
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