芪连汤与降糖药联合干预2型糖尿病胰岛素抵抗及对相关炎症细胞因子的影响

目的 观察芪连汤与相应降糖药协同对2型糖尿病患者胰岛素敏感性的作用及相关炎症细胞因子的影响。方法 选择2型糖尿病患者62例，随机分为两组，两组均常规应用西药降糖药，治疗组同时加用芪连汤口服，每日1剂，分2次服，疗程4周。并测定两组治疗前后空腹血糖、胰岛素、C肽、肿瘤坏死因子α(TNFα)、C反应蛋白(CRP)、白细胞介素6(IL-6)含量，计算胰岛素敏感指数(ISI)。结果 两组空腹血糖治疗后均比治疗前显著下降(P<0．01)；治疗组胰岛素、C肽、IsI、TNFd、IL-6和CRP含量治疗后比治疗前明显下降(P<0．05或P<0．01)，且治疗组优于对照组(P<0．05或P<0．01)。结论 芪连汤对改善胰岛素抵抗及降低相关炎症细胞因子水平有一定作用。

Preliminary Exploration on Effect of Qilian Decoction in Intervention Treatment of Diabetes Mellitus Type 2 with Insulin Resistance and Its Influence on Related Inflammatory Cytokines

OBJECTIVE: To observe the synergistic effect of Qilian decoction (QLD) with corresponding hypoglycemic agents on insulin sensitivity in patients with diabetes mellitus type 2 and its influence on related inflammatory cytokines. METHODS: Sixty-two patients with diabetes mellitus type 2 were selected and randomly divided into two groups, they were treated with hypoglycemic agent in routine, and QLD was given orally, one dose taken in twice a day. Parameters as fasting blood glucose, insulin, peptide C, tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukin 6 (IL-6) were measured before and after treatment, and insulin sensitive index (ISI) was also calculated. RESULTS: The level of fasting blood glucose lowered after treatment in both groups (P<0.01); levels of fasting insulin, peptide C, ISI, TNF-alpha, IL-6 and CRP significantly lowered after treatment (P<0.05 or P<0.01), and the effect was better than that in the control group (P<0.05 or P<0.01). CONCLUSION: QLD could improve the insulin resistance and lower the levels of related inflammatory cytokines.