七味开心颗粒对脑损伤-嗅球破坏模型大鼠行为及血浆中ACTH、COR含量的影响

目的 :研究七味开心颗粒的药理作用。方法 :采用脑损伤 -嗅球破坏模型 ,将实验大鼠分为正常组、假手术组、模型组、盐酸氯米帕明组、七味开心颗粒 (高、中、低剂量 )组 ,观察各组大鼠行为学变化及其血浆中促肾上腺皮质激素 (ACTH )和皮质醇 (COR)含量的变化。结果 :在敞箱实验和避暗实验中 ,模型组大鼠行为出现明显变化 ,七味开心颗粒组和盐酸氯米帕明组均可显著拮抗大鼠行为变化 ;模型组大鼠血浆中ACTH、COR含量显著升高 (P<0 01) ,七味开心颗粒组和盐酸氯米帕明组都可抑制ACTH、COR含量的升高 (P<0 01)。结论 :七味开心颗粒可能通过作用于下丘脑 -垂体 -肾上腺皮质轴而发挥抗抑郁作用。

Study on the Effects of Qiweikaixin Granules on the Behaviors of Brain Injured- Olfactory Bulb Damage Type Rats and on the Contents of ACTH and COR in Plasma

OBJECTIVE:To study the pharmacological action of Qiweikaixin Granules.METHODS:Brain injured-olfacˉtory bulb damage type was adopted,and the rats were divided into normal control group,pseudo-operation group,model group,hydrochloric acid clomipramine group and Qiweikaixin Granules(high,moderate,mild dosage)group,the behaviors of each group was observed,the contents of adrenocorticotrophic hormone corticotrophin(ACTH)and cortisol(COR)in plasma were also observed.RESULTS:In both the open field test and the heliophobic test,the behaviors of the model group had obvious changes;both the Qiweikaixin Granule group and the hydrochloric acid clomipramine group significantly resisted the change of behaviors of rats;the contents of ACTH and COR in the plasma of the model rats group increased significantly(P< 0.01),yet those in the Qiweikaixin Granule group and the hydrochloric acid clomipramine group could be restrained from inˉcreasing(P<0.01).CONCLUSION:It is probably by acting on the subthalamus-pituitary-adrenal cortex axis that Qiweika_ ixin Grain produces an antidepressant effect.