慢性丙型肝炎患者血清抗-HCV及HCVRNA水平与病情的关系研究

目的 探讨慢性丙型肝炎患者血清抗-HCV水平和HCVRNA含量与病情的关系。方法 应用微粒子发光法检测抗-HCV水平，应用荧光定量PCR技术检测HCVRNA含量，并与病情进行相关性分析。结果 血清抗-HCV水平〉100 S／CO时，HCVRNA含量较高，且大多数患者血清ALT升高；当HCVRNA含量较高时，抗-HCV水平及ALT同步异常。结论 HCVRNA含量与抗-HCV水平在一定程度上均能反映HCV的复制情况，且与病情密切相关，应同步检测。

The Relationship between the Serum Level of HCVRNA,Anti-HCV and the Clinical Symptom of Patients with Chronic Hepatitis C

Objective To study the relationship between the serum level of HCVRNA,Anti-HCV and the clinical symptom of the patients with chronic hepatitis C.Methods The level of Anti-HCV and HCVRNA in the serum is detected by Microparticle Enzyme Immunoassay (MEIA)and Fluorescent Quantitative Polymerase Chain Reaction (FQ-PCR),and the correlation with clinical symptom of the patients with chronic hepatitis C is analyzed.Results The serum level of HCVRNA was higher when the level of Anti-HCV more than 100 S/CO,and the level of ALT was in preternatural range;The serum level of Anti-HCV and ALT were in preternatural range when the level of HCVRNA was higher.Conclusion The results show that the serum level of Anti-HCV and HCVRNA is of great value in evaluating the degree of inflammative activity in liver,but the level of Anti-HCV and HCVRNA synchronization should be detected at the same time.