The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin |
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Authors: | Wigger-Alberti Walter Spoo Julia Schliemann-Willers Sibylle Klotz Andreas Elsner Peter |
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Institution: | Department of Dermatology, Friedrich-Schiller-University, Jena, Germany. |
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Abstract: | The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual score, transepidermal water loss, chromametry and skin capacitance. Concurrent application of SLS/toluene induced stronger reactions than those caused by twice daily application of each irritant on its own. A protective effect of the protective cream was obtained against all treatment combinations and was significant for SLS/SLS (p < or = 0.01) and SLS/ toluene (p < or = 0.05). Our results indicate that the tandem repetitive irritation test has great potential in the evaluation of skin care products to prevent irritant contact dermatitis. |
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