| P~(75 NGFR)在先天性胆总管囊肿的表达意义初探 |
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| 引用本文： | 郑练,黄杰雄,陈建中,谢斌,陈伦家,陈展硕. P~(75 NGFR)在先天性胆总管囊肿的表达意义初探[J]. 中国普外基础与临床杂志, 2001, 0(5) |
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| 作者姓名： | 郑练 黄杰雄 陈建中 谢斌 陈伦家 陈展硕 |
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| 作者单位： | 汕头大学医学院第一附属医院小儿外科，汕头大学医学院第一附属医院病理科，汕头大学医学院第一附属医院肝胆外科，汕头大学医学院第一附属医院病理科，汕头大学医学院第一附属医院小儿外科，湖南医科大学附属湘雅医院小儿外科 汕头515041，汕头515041，长沙410008 |
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| 摘 要： | 目的 探讨神经生长因子受体 (P75NGFR)在先天性胆总管囊肿 (CCC)的分布情况及其意义。方法 应用免疫组化方法对 1 8例先天性胆总管囊肿患儿及 9例对照组的胆总管进行检测。结果 丰富的P75NGFR染色阳性神经纤维分布于正常胆总管外膜下 ,神经节细胞表现为P75NGFR染色强阳性 ;先天性胆总管囊肿的P75NGFR染色阳性纤维明显减少。结论 P75NGFR在先天性胆总管囊肿的异常分布可能与CCC的发病机理有关。
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| 关 键 词： | 先天性胆总管囊肿 免疫组织化学 神经生长因子受体 |
THE IMPLICATION OF P~(75 NGFR) EXPRESSION IN CONGENITAL CHOLEDOCHAL CYST |
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| ZHENG Lian ,HUANG Jie xiong,CHEN Jian zhong,et al.. THE IMPLICATION OF P~(75 NGFR) EXPRESSION IN CONGENITAL CHOLEDOCHAL CYST[J]. Chinese Journal of Bases and Clinics In General Surgery, 2001, 0(5) |
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| Authors: | ZHENG Lian HUANG Jie xiong CHEN Jian zhong et al. |
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| Affiliation: | ZHENG Lian *,HUANG Jie xiong,CHEN Jian zhong,et al. *Department of Pediatric Surgery,First Affiliated Hospital,Shantou University Medical College,Shantou 515041 |
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| Abstract: | Objective To evaluate the distribution of nerve growth factor receptor( P 75 NGFR ) in congenital choledochal cyst(CCC) and its clinical implication. Methods Specimens from 18 children with CCC and normal choledochal specimens from 9 controls were immuno stained with P 75 NGFR antibody. Results Extensive P 75 NGFR staining was found in the nerve fibres of normal comnon bile duct,strongly staining of ganglion cells were observed on the normal specimens. There was very little immunoreactive fibre in the CCC. Conclusion The abnormal distribution of P 75 NGFR in the aganglionic choledochal suggests that abnormal P 75 NGFR is related to the occurrance of the CCC. |
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| Keywords: | Congenital choledochal cyst Immunohistochemical Nerve growth factor receptor |
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