术前局部注射^131I—3H11导向治疗胃癌的临床研究

目的 探讨术前应用免疫导向技术治疗胃癌的临床效果。方法 以应用^131I-3H11对6例胃癌病人术前行内镜下癌灶多点注射作为治疗组；选择6例胃癌病人采用FAM方案化疗作为对照组。并对术后标本进行观察。结果 术后病理检查治疗组发现75．0％（12／16）出现癌细胞核固缩、破裂、细胞浆凝固、细胞间质出现炎性细胞浸润；这些变化多以中度为主，重度及无变化较少；而对照组无明显变化。结论 作为胃癌的综合治疗方法，术前胃癌局部注射^131I－3H11具有临床应用前景。

Clinical study of preoperative immunoguiding therapy of intratumor injection of ~( 131) I-3H11 for gastric carcinoma

Objective To investigate the effect of intratumor injection of 131 I 3H11 for gastric cancer (GC). Methods 16 patients with GC subjected to endoscopic intratumor injection of 131 I 3H11 as a treatment group; 6 GC patients with FAM chemotherapy as a control group. Histological examination of the postoperative specimens of the two group were comparated. Results In treatment group, 75.0%(12/16) of cases were found to have morphological changes with karyopyknosis, karyorrhexis, coagulation of cytoplasm, and invasion of lymphocyte in mesochyma. Most of these changes were medial; but in control group no obvious morphological change was found. Conclusions The results suggest that GC subjected to endoscopic intratumor injection of 131 I 3H11 preoperatively has promising application in the clinic.