Nucleotide sequence of the avian influenza virus A/fowl plague/Rostock/34 segment 1 encoding the PB2 polypeptide |
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| Authors: | Isabel J. Roditi James S. Robertson |
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| Affiliation: | Division of Virology, Department of Pathology, University of Cambridge, Laboratories Block, Addenbrooke''s Hospital, Cambridge CB2 2QQ U.K. |
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| Abstract: | The nucleotide sequence of segment 1 of fowl plague virus (A/FPV/Rostock/34) was determined from a DNA copy inserted at the Pst I site of pBR322. Segment 1 is 2341 nucleotides long and encodes a highly basic protein of 759 amino acid residues (PB2). This protein forms part of the viral polymerase complex and is involved in the recognition of cap structures and endonucleolytic cleavage of eukaryotic mRNAs. Comparisons made between segment 1 of fowl plague virus and three human strains of influenza virus show approximately 85% nucleotide sequence homology and 94% homology between amino acid sequences. |
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| Keywords: | influenza virus FPV/Rostock sequence of RNA segment 1 sequence of PB2 polypeptide |
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