Influence of histological inflammatory activity on regenerative capacity of liver after percutaneous transhepatic portal vein embolization |
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Authors: | Hiromu Tanaka Kazuhiro Hirohashi Shoji Kubo Takashi Ikebe Tadashi Tsukamoto Hiroyuki Hamba Taichi Shuto Kenichi Wakasa Hiroaki Kinoshita |
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Institution: | (1) Second Department of Surgery, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, JP;(2) Department of Pathology, Osaka City University Hospital, Osaka, Japan, JP |
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Abstract: | Percutaneous transhepatic portal vein embolization (PTPE) produces regenerative hypertrophy in the nonembolized part of the
liver, but the regenerative capacity after PTPE in patients with chronic hepatitis is unknown. We studied 34 patients with
hepatocellular carcinoma and chronic hepatitis who underwent PTPE at the right portal vein. Hepatic lobular volumes were calculated
by computed tomography before and 2 weeks after PTPE. The increase in left lobular volume was analyzed using a stepwise multiple
regression method incorporating 11 factors: age; portal venous pressure; proportional volume of the right lobe; indocyanine
green retention test; platelet count; serum levels of aspartate transaminase, alanine transaminase, total bilirubin, and albumin;
and histological inflammatory grade and stage of fibrosis, according to the criteria of the International Association for
the Study of the Liver recommended at their 1994 meeting. The median volume of the left lobe had increased from 405 to 554
cm3 (P < 0.0001) by 2 weeks after PTPE. Inflammatory grade was the only independent factor predicting regenerative hypertrophy (regeneration
ratio (%) = 80.3 − 20.1 × grade; standard correlation coefficient = −0.566; P = 0.0014). Histological inflammatory activity was the essential factor regulating liver regeneration after PTPE in patients
with chronic hepatitis.
(Received May 14, 1998; accepted Aug. 28, 1998) |
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Keywords: | : liver regeneration chronic hepatitis portal vein embolization |
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