Synthesis and antioxidant properties of 3-methyl-substituted thiazolo[3,2-a]benzimidazole

3-Aminomethyl-substituted thiazolo3,2-a]benzimidazoles were synthesized by reacting 3-(chloromethyl) thiazolo3,2-a]benzimidazole with primary and secondary amines. The resulting 3-amino-derivatives of thiazolobenzimidazole were tested in vitro for antioxidant properties in relation to the autooxidation of adrenaline to adrenochrome. All the compounds studied inhibited, to different extents, the oxidation of adrenaline to adrenochrome, thus preventing formation of the superoxide radical. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 6, pp. 20–21, June, 2007.