含链霉素短程化疗方案的痰结核菌转阴时间观察

目的对比短程化疗含链霉素(SM)、乙胺丁醇(EMB)两组方案在抗结核治疗中的效果。方法选初治菌阳肺结核100例,予含SM方案(2HRZS/7HR)化疗50例,含EMB方案(2HRZE/7HR)化疗50例。每月检查痰结核菌一次(涂片三次,培养一次)。停药后继续追踪两年。结果痰菌2个月内转阴者,SM组29例,占63%;EMB组18例,占38%,p<0.05,有显著性差异。需延长强化期者:SM组16例,占35%;EMB组26例,占55%,p<0.05,有显著性差异。复发病例,SM组2例,占4%;EMB组3例,占6%,p>0.05,无显著性差异。结论使用含SM方案化疗的病例其痰菌转阴时间比含EMB方案短。

SHORT - TERM STREPTOMYCIN - CONTAINING REGIMEN GREATLY REDUCES THE TIME NEEDED TO ERADICATE MYCOBACTEIUM TUBERCULOSIS FROM THE LUNGS OF INFECTED HUMAN

Objective To compare tow different short-term regimen's efficacies in anti-tuberculosis.Method One hundred patients who accompanied by bacillary pulmonary tuberculosis and treated firstly were included in the study and randomized into two groups:Streptomycin-containing group(group SM,2HRZS/7HR) or EMB-containing group(EMB group,2HRZE/7HR),respectively,with fifty patients in each group.Check-up of the mycobacterium tuberculosis were made monthly i.e.sputum smearing three times,sputum culture one time,thereafter,follow up for 2 years after withdraw of the treatment.Result Culture conversions within 2 months after initiation of treatment were 29 cases(63%)in SM group,18 cases(38%)in EMB group,respectively(p<0.05).Need long-drawn time of treatment used four drugs was 16 cases(35%) in SM group,and 26 cases(55%) in EMB group,respectively(p<0.05).Relapses were occurred in 2 cases(4%) in SM group,and in 3cases(6%) in EMB group(p>0.05).Conclusion Streptomycin-containing regimen has the potential to substantially shorten the duration of therapy need to cure human tuberculosis.